Methods A descriptive study was performed.The clinical data from 8 eyes of 4 patients with Peters anomaly who were diagnosed and treated in Beijing Children's Hospital from January 1,2014 to March 30,2016 were retrospectively analyzed.The clinical manifestations of the anterior ocular segment were examined by handheld slit-lamp microscope,and corneal curvature,corneal thickness,axial length and intraocular pressure were measured.The therapy and outcomes of the patients were evaluated.Results Peters anomaly was classified into type Ⅰ,type Ⅱ and Peters plus syndrome based on the findings and literature'criteria.Regarding to the clinical findings,the adhesion of peripheral angle with cornea,shallow or disappeared anterior chamber were found in all the eyes,and these manifestations were type Ⅰ Peters anomaly and occurred in 2 eyes of 2 patients.The opacity and adhesion of the central lens capsula to corneal endothelium was seen in 6 eyes which belonged to type Ⅱ Peters anomaly.The mean corneal thickness was (680± 127) μm in 4 measured eyes,which was thicker than normal eyes the mean corneal curvature was (37.40☑.79)D in 4 measured eyes the mean axial length was (21.06☐.19)mm and the mean diameter of cornea was (9.4 ± 0.5) mm in 4 measured eyes.Iridocoloboma was found in 4 eyes and congenital aniridia was in 4 eyes.In addition, esotropia appeared in 1 patient,and nystagmus occurred in 3 patients.The 3 patients of type Ⅱ in this study were found to have the disorders associated with systemic neurogenic developmental abnormalities and diagnosed as Peters plus syndrome. Understanding the clinical features of Peters anomaly is helpful for us to correctly manage this disease.Objective This study was to investigate the clinical characteristics and treatment methods of Peters anomaly and provide available basis for the diagnosis and individualized treatment of Peters abnormal.
Many patients with Peters’ anomaly may not develop good vision in the involved eye(s) even with treatment.Background Peters anomaly is a rare eye disease. Your doctor may or may not recommend a corneal transplant based on many different factors.
Corneal transplants can be challenging in children. Patients should be monitored for glaucoma and can be evaluated for possible corneal transplant, a procedure to replace the cornea with a clear donor cornea to allow vision to develop. Treatment for Peters’ anomaly in a child is challenging. Sometimes Peters’ anomaly is inherited, but most of the time it is not. Patients may need to be evaluated by a genetic specialist or other specialists to have a complete picture of the condition for that child. Sometimes Peters’ anomaly can be caused an abnormal gene or chromosome. These patients have what is called Peters’ plus. A child may have a cataract, changes in the structure of the iris which is the colored portion of the eye (conditions called coloboma or aniridia), glaucoma (a condition in which the eye pressure is elevated), or under development of other structures in the eye.Ībout 60% of patients will also have other health conditions such as a change in appearance or growth, a heart condition, delay in development, or other abnormalities in the nervous system.
In addition to the clouding of the cornea, other structures in the eye may also be abnormal. Peters’ anomaly is a congenital condition, meaning that a child is born with the condition. This clouding of the cornea can block the development of vision. Peters’ anomaly is a condition that causes the cornea, the clear window in the front of the eye, to be opaque or cloudy rather than clear.